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La Jolla Cosmetic Surgery Centre & Medical Spa
9850 Genesee Ave Suite 130
La Jolla, CA 92037
Call: (858) 452-1981 Text: (858) 203-2944
Monday–Friday: 7:30 a.m.–6 p.m.
La Jolla Cosmetic Medical Spa - Carlsbad
7730 El Camino Real Suite C
Carlsbad, CA 92009
Call: (858) 788-7989 Text: (858) 203-2944
Monday–Friday: 8 a.m.–8 p.m.
Saturday: 9 a.m.–5 p.m.
When it comes to getting a totally natural look with fillers, one size does NOT fit all—and the popular filler manufacturer Restylane understands this. The most recent additions to the Restylane® family, Restylane Refyne and Restylane Defyne, available at our San Diego and Carlsbad locations, are great options to smooth moderate to deep facial lines and folds.
All Restylane fillers are gels made from hyaluronic acid (HA), a naturally occurring substance in the skin that can hold many times its weight in water and works fabulously to help restore facial volume and smooth lines and wrinkles.
Refyne and Defyne are made with the latest technology, XpresHAn™, which blends the HA particles in a way that lets the filler move more naturally with your facial expressions. While your injectable provider’s skill matters most in achieving an effective, natural-looking result, Refyne and Defyne are designed to help avoid the stiff or unnatural feeling that can sometimes occur with deeper filler injections in parts of the face that move frequently and dynamically.
Keep in mind that each patient is unique and your results may vary.
Refyne and Defyne are very similar products, with slightly different consistencies. Defyne is slightly thicker and therefore can be injected a little more deeply to treat more severe folds (it may help to think the “D” in Defyne stands for “deep”).
Our experienced providers can determine the best product for you during your free personal consultation..
The price of Restylane Refyne and Defyne at our La Jolla and Carlsbad med spas is typically $750+. Be sure to visit our specials page for current rebates, deals, and specials. Learn more about our injectables fees.
| Procedure | Fee Range |
| Restylane® Defyne & Refyne | $750 & up |
| Restylane® Dermal Fillers | $525–$690 |
| Restylane® Lyft | $750–$795 |
Our plastic surgeons and PA/RN providers use a very thin, short needle to inject the filler, which is infused with the mild anesthetic lidocaine to enhance comfort. Most patients experience a brief pinching sensation and pressure during treatment. Numbing cream may be used to help with discomfort.
95.6% Patient Satisfaction
* These are actual patient comments verified by a 3rd party. The claims made represent the opinion of the author.
Every patient deserves a comfortable experience, so we now offer an add-on option to use PRO-NOX™, a self-administered nitrous oxide (laughing gas) system that allows you to be in full control of your comfort.
If at any point you feel you need something to take the edge off, simply breathe through the PRO-NOX™ mouthpiece for instant relief from pain and anxiety. Unlike oral pain medication, PRO-NOX™ takes effect in seconds, but these effects wear off minutes. You can safely drive and return to your normal routine without worrying about side effects.
Ask us about adding PRO-NOX™ to your treatment at your consultation, or contact us for more information!
Restylane Refyne/Defyne both typically last about 9 to 12 months. However, everyone is different. Some patients are happy with their results for longer than a year, while others choose to repeat treatment more frequently.
Hyaluronic acid fillers, such as Restylane products, are safely absorbed by the body and metabolized and eliminated naturally over time. If you’re interested in a filler that will last longer than 12 months, you may consider Sculptra.
Since 1988, more than 36,000 patients have had safe, successful procedures at La Jolla Cosmetic Surgery Centre & Medical Spa.
We reserve time in our schedules for fillers and BOTOX appointments. Click to book a free virtual consultation or in-office treatment or contact us at (858) 452-1981 with additional questions about the procedure. We can also see you during your lunch break, or in the evening on certain days of the week. Call (858) 452-1981 to check availability.
Yes, there are a whole lot of fillers on the market—and choosing the right one takes an experienced provider’s help. LJC certified aesthetic nurse specialist Brittany Haley, RN-BSN, explains how she approaches filler choices.
Last reviewed by a La Jolla Cosmetic Surgery Centre & Medical Spa Editor on January 23rd, 2023. Meet Our Medical Editors
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